منابع مشابه
Immunodeficiency: Trapping the nude mouse gene
Hairless nude mice are immunodeficient because they lack a thymus. The nude gene has now been identified; it encodes a winged-helix transcription factor that is expressed specifically in skin and thymus.
متن کاملTumorigenicity of Esophageal Cancer Stem Cells (ECSCs) in nude mouse xenograft model
Background and objectives: Modeling cancer in vivo is a very important tool to investigate cancer pathogenesis and molecular mechanisms involved in cancer progression. Laboratory mice are the most common animal used for rebuilding human cancer in vivo. Cancer stem cells (CSCs) are the main reason of failure in cancer therapy because of tumor relapse and metastasis. Isolation of cancer stem cell...
متن کاملHeterotransplantation of retinoblastoma into the athymic "nude" mouse.
Fresh surgical specimens of retinoblastoma were successfully transplanted into the anterior chamber of the "nude" mouse (a homozygous mutant, nu/nu, with a severe defect in cellular immunity), filling the eyes but failing to grow subcutaneously. Retinoblastoma cells from an established cell line, Y-79,1 spread from the intraocular injection site to invade the orbit, optic nerve, and brain and f...
متن کاملHeterotransplantation of human choroidal melanoma into the athymic "nude" mouse.
The investigation of the structure and behavior of malignant melanoma of the uveal tract in man has been limited by the lack of a ready source of human tumor and an animal model in which the tumor resembles that in the human choroid. We now report the observation that fresh surgical specimens of human choroidal melanoma can be successfully transplanted into the posterior segment of the "nude" m...
متن کاملInduction and abrogation of unresponsiveness in nude mouse cells
Nude mice were injected with antigen and T cells at different times to induce unresponsiveness to SRBC. Spleen cells derived from these mice were tested in vitro for the capability to produce antibody-forming cells against sheep erythrocytes in the presence of a T-cell-replacing factor. It was found that priming with antigen alone did not result in paralysis but a later injection of thymus-deri...
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ژورنال
عنوان ژورنال: ILAR Journal
سال: 1992
ISSN: 1084-2020
DOI: 10.1093/ilar.34.1-2.1